Immunocytochemical localization of cleaved caspase-3 in pancreatic islets from type 1 diabetic subjects
نویسندگان
چکیده
منابع مشابه
Evaluation of Ficolin-3 (FCN3) 1637delC (rs28357092) Frameshift Mutation in Iranian Type 2 Diabetic Subjects
Background and Aims: Ficolins are proteins that bind to carbohydrates, act as opsonins and play an important role in innate immunity. Polymorphism in ficolin-3 gene (FCN3) can lead to complement deficiency and increase the risk of some disorders such as diabetes. The aim of this study was to investigate the frequency of FCN3+1637delC as a single nucleotide polymorphism in this gene in healthy a...
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Exercise appears to improve glycemic control for people with type 1 diabetes (T1D). However, the mechanism responsible for this improvement is unknown. We hypothesized that exercise has a direct effect on the insulin-producing islets. Eight-week-old mice were divided into four groups: sedentary diabetic, exercised diabetic, sedentary control, and exercised control. The exercised groups particip...
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The rat pancreas has frequently been used as an animal model to study changes in islet cells in pathological conditions, such as diabetes mellitus and islet cell tumours, but detailed quantitative data on the islets are not available. This study was therefore undertaken to investigate (1) the volume density of pancreatic islets, (2) islet diameter, islet volume and islet cell number and (3) isl...
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The transcription factor p73 is a homologue of p53 that can be expressed as pro- or anti-apoptotic isoforms. Unlike p53, p73 is rarely mutated or lost in cancers and it is found to replace defective p53 inducing apoptosis. Here, we investigated the p73 involvement in anoikis, a type of apoptosis caused by inadequate cell-matrix interactions. Breast cancer cell lines with different p53 status we...
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Type 1 diabetes is the clinical manifestation of aberrant leukocytic infiltration of the pancreatic islets; it is usually diagnosed only very late in disease progression, after the critical autoimmune phenomena have mostly played out. A noninvasive means of directly monitoring the evolution of islet infiltrates would have important research and clinical applications. We have exploited fluoresce...
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ژورنال
عنوان ژورنال: Islets
سال: 2010
ISSN: 1938-2014,1938-2022
DOI: 10.4161/isl.2.1.10041